RSS Manchester - June 11th 2003

Royal Statistical Society
Manchester Local Group

June 11th 2003 at MMU at 4.30pm for 5.00pm

This meeting will include a very short AGM and report

Graham Dunn (Biostats Group at Manchester University)

The challenge of patient choice and non-adherence to treatment in RCTs of counselling and psychotherapy

The talk will start with a short and relatively non-technical review of recent statistical ideas on the analysis and interpretation of results of RCTs in which there might be non-adherence to allocated treatment. This involves the use of potential outcomes (counterfactuals) in the definition and estimation of treatment effects. The ideas will be illustrated using data from the ODIN trial (BMJ 321, 1450-4, 2000). I will then move on to discuss how such methods might help us to evaluate the potential of partially- randomised 'patient preference' designs and to compare them with other, possibly more promising, alternatives.

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